Viscosupplementation for OA Treatment
Hyaluronic Acid (HA) is a natural polysaccharide which moisturizes and lubricates soft tissue of the body. It is linear polymers of the repeating disaccharide structure by alternate addition of glucuronic acid and N-acetylglucosamine. With its high ability to bind and retain water, HA is a lubricant and a viscosupplement in the articular cavity of knee, shoulder, hip and ankle which effectively protects the cartilage.
Global Qualification of LG Chem's Hyaluronic Acid
LG Chem's Hyaluronic Acid Platform Technology
LG Chem's bacterial-fermented HA has been applied as a platform for a variety of medicinal products over 25 years.
[ Global Qualifications ]
- In 2004, US FDA DMF submitted.
- In 2005, EDQM Certificate of Suitability granted.
Crosslinking reaction of linear HA leads to delay in drug degradation by free radicals and enzymes in the body.
Crosslinking reaction forms HA polymer chains into a three-dimensional network HA hydrogels.
Bio-stability
The retention of Hyruan One is maintained longer compared to 3-injection in the articular cavity.
Synovial Fluid-like Viscoelasticity
Hyruan One was designed to restore the viscoelasticity of the synovial fluid when mixed in the knee joint of OA patients.
Pain Reduction
Hyruan One was designed to restore the viscoelasticity of the synovial fluid when mixed in the knee joint of OA patients.
Hyruan One remain effective for 39 weeks after second treatment.
Pain stiffness and function test
Pain and functional score of Hyruan One was equivalent to Hyruan Plus.
Hyruan One remain effective for 39 weeks after second treatment.
Safety over repeated injection
Hyruan One showed less AE after repeated injection.
Improve user convenient
Hyruan One is provided as an all-in-one kit with a thin-wall needle to maximize user convenient.
ONE solves it all
